mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity

BACKGROUND: The RNA helicase eIF4A1 is a key component of the translation initiation machinery and is required for the translation of many pro-oncogenic mRNAs. There is increasing interest in targeting eIF4A1 therapeutically in cancer, thus understanding how this protein leads to the selective re-pr...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Waldron, Joseph A., Tack, David C., Ritchey, Laura E., Gillen, Sarah L., Wilczynska, Ania, Turro, Ernest, Bevilacqua, Philip C., Assmann, Sarah M., Bushell, Martin, Le Quesne, John
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936103/
https://ncbi.nlm.nih.gov/pubmed/31888698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1901-2
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