BACE1 partial deletion induces synaptic plasticity deficit in adult mice

BACE1 is the first enzyme involved in APP processing, thus it is a strong therapeutic target candidate for Alzheimer’s disease. The observation of deleterious phenotypes in BACE1 Knock-out (KO) mouse models (germline and conditional) raised some concerns on the safety and tolerability of BACE1 inhib...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lombardo, Sylvia, Chiacchiaretta, Martina, Tarr, Andrew, Kim, WonHee, Cao, Tingyi, Sigal, Griffin, Rosahl, Thomas W., Xia, Weiming, Haydon, Philip G., Kennedy, Matthew E., Tesco, Giuseppina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934620/
https://ncbi.nlm.nih.gov/pubmed/31882662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56329-7
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