BACE1 partial deletion induces synaptic plasticity deficit in adult mice

BACE1 is the first enzyme involved in APP processing, thus it is a strong therapeutic target candidate for Alzheimer’s disease. The observation of deleterious phenotypes in BACE1 Knock-out (KO) mouse models (germline and conditional) raised some concerns on the safety and tolerability of BACE1 inhib...

全面介紹

Na minha lista:
書目詳細資料
發表在:Sci Rep
Main Authors: Lombardo, Sylvia, Chiacchiaretta, Martina, Tarr, Andrew, Kim, WonHee, Cao, Tingyi, Sigal, Griffin, Rosahl, Thomas W., Xia, Weiming, Haydon, Philip G., Kennedy, Matthew E., Tesco, Giuseppina
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934620/
https://ncbi.nlm.nih.gov/pubmed/31882662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56329-7
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍