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BACE1 partial deletion induces synaptic plasticity deficit in adult mice
BACE1 is the first enzyme involved in APP processing, thus it is a strong therapeutic target candidate for Alzheimer’s disease. The observation of deleterious phenotypes in BACE1 Knock-out (KO) mouse models (germline and conditional) raised some concerns on the safety and tolerability of BACE1 inhib...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6934620/ https://ncbi.nlm.nih.gov/pubmed/31882662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56329-7 |
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