Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling

Tyrosine kinase inhibitors (TKIs) induce molecular remission in the majority of patients with chronic myelogenous leukemia (CML), but the persistence of CML stem cells hinders cure and necessitates indefinite TKI therapy. We report that CML stem cells upregulate the expression of pleiotrophin (PTN)...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Himburg, Heather A., Roos, Martina, Fang, Tiancheng, Zhang, Yurun, Termini, Christina M., Schlussel, Lauren, Kim, Mindy, Pang, Amara, Kan, Jenny, Zhao, Liman, Suh, Hyung, Sasine, Joshua P., Sapparapu, Gopal, Bowers, Peter M., Schiller, Gary, Chute, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934217/
https://ncbi.nlm.nih.gov/pubmed/31613796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129061
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados