Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains

Alterations of the PALB2 tumor suppressor gene have been identified in familial breast, ovarian and pancreatic cancer cases. PALB2 cooperates with BRCA1/2 proteins through physical interaction in initiation of homologous recombination, in maintenance of genome integrity following DNA double-strand b...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Park, Dongju, Shakya, Reena, Koivisto, Christopher, Pitarresi, Jason R., Szabolcs, Matthias, Kladney, Raleigh, Hadjis, Ashley, Mace, Thomas A., Ludwig, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932818/
https://ncbi.nlm.nih.gov/pubmed/31877165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226714
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