Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation

Oncolytic viruses represent an emerging approach to cancer therapy. However, better understanding of their interaction with the host cancer cell and approaches to enhance their efficacy are needed. Here, we investigate the effect of chemically induced endoplasmic reticulum (ER) stress on the activit...

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Bibliographic Details
Published in:Mol Ther Oncolytics
Main Authors: Taverner, William K., Jacobus, Egon J., Christianson, John, Champion, Brian, Paton, Adrienne W., Paton, James C., Su, Weiheng, Cawood, Ryan, Seymour, Len W., Lei-Rossmann, Janet
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931121/
https://ncbi.nlm.nih.gov/pubmed/31890865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.09.003
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