Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer

Overexpression of drug efflux transport ABCB1 is correlated with multidrug resistance (MDR) among cancer cells. Upregulation of ABCB1 accounts for the recurrence of resistance to docetaxel therapy in ovarian cancer with poor survival. Erastin is a novel and specific small molecule that targets SLC7A...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Zhou, Hai-Hong, Chen, Xu, Cai, Lu-Ya, Nan, Xing-Wei, Chen, Jia-Hua, Chen, Xiu-Xiu, Yang, Yang, Xing, Zi-Hao, Wei, Meng-Ning, Li, Yao, Wang, Sheng-Te, Liu, Kun, Shi, Zhi, Yan, Xiao-Jian
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930896/
https://ncbi.nlm.nih.gov/pubmed/31921655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01398
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