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Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer
Overexpression of drug efflux transport ABCB1 is correlated with multidrug resistance (MDR) among cancer cells. Upregulation of ABCB1 accounts for the recurrence of resistance to docetaxel therapy in ovarian cancer with poor survival. Erastin is a novel and specific small molecule that targets SLC7A...
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| Publicado no: | Front Oncol |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6930896/ https://ncbi.nlm.nih.gov/pubmed/31921655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01398 |
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