Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer

Overexpression of drug efflux transport ABCB1 is correlated with multidrug resistance (MDR) among cancer cells. Upregulation of ABCB1 accounts for the recurrence of resistance to docetaxel therapy in ovarian cancer with poor survival. Erastin is a novel and specific small molecule that targets SLC7A...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Zhou, Hai-Hong, Chen, Xu, Cai, Lu-Ya, Nan, Xing-Wei, Chen, Jia-Hua, Chen, Xiu-Xiu, Yang, Yang, Xing, Zi-Hao, Wei, Meng-Ning, Li, Yao, Wang, Sheng-Te, Liu, Kun, Shi, Zhi, Yan, Xiao-Jian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930896/
https://ncbi.nlm.nih.gov/pubmed/31921655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01398
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