Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass

Methylprednisolone is used in neonates to modulate cardiopulmonary bypass (CPB)–induced inflammation, but optimal dosing and exposure are unknown. We used plasma methylprednisolone and interleukin (IL)‐6 and IL‐10 concentrations from neonates enrolled in a randomized trial comparing one vs. two dose...

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Veröffentlicht in:CPT Pharmacometrics Syst Pharmacol
Hauptverfasser: Hornik, Christoph P., Gonzalez, Daniel, Dumond, Julie, Wu, Huali, Graham, Eric M., Hill, Kevin D., Cohen‐Wolkowiez, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930860/
https://ncbi.nlm.nih.gov/pubmed/31646767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12470
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