Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass

Methylprednisolone is used in neonates to modulate cardiopulmonary bypass (CPB)–induced inflammation, but optimal dosing and exposure are unknown. We used plasma methylprednisolone and interleukin (IL)‐6 and IL‐10 concentrations from neonates enrolled in a randomized trial comparing one vs. two dose...

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Bibliografiske detaljer
Udgivet i:CPT Pharmacometrics Syst Pharmacol
Main Authors: Hornik, Christoph P., Gonzalez, Daniel, Dumond, Julie, Wu, Huali, Graham, Eric M., Hill, Kevin D., Cohen‐Wolkowiez, Michael
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930860/
https://ncbi.nlm.nih.gov/pubmed/31646767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12470
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