Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass

Methylprednisolone is used in neonates to modulate cardiopulmonary bypass (CPB)–induced inflammation, but optimal dosing and exposure are unknown. We used plasma methylprednisolone and interleukin (IL)‐6 and IL‐10 concentrations from neonates enrolled in a randomized trial comparing one vs. two dose...

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Publicat a:CPT Pharmacometrics Syst Pharmacol
Autors principals: Hornik, Christoph P., Gonzalez, Daniel, Dumond, Julie, Wu, Huali, Graham, Eric M., Hill, Kevin D., Cohen‐Wolkowiez, Michael
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930860/
https://ncbi.nlm.nih.gov/pubmed/31646767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12470
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