The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation

PURPOSE: Silicosis is an occupational disease caused by inhalation of silica and there are no effective drugs to treat this disease. Tanshinone IIA (Tan IIA), a traditional natural component, has been reported to possess anti-inflammatory, antioxidant, and anti-fibrotic properties. The current study...

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Udgivet i:Drug Des Devel Ther
Main Authors: Feng, Feifei, Cheng, Peng, Zhang, Huanan, Li, Nannan, Qi, Yuxin, Wang, Hui, Wang, Yongbin, Wang, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930391/
https://ncbi.nlm.nih.gov/pubmed/31908414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S230572
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