Sodium tanshinone IIA sulfonate suppresses pulmonary fibroblast proliferation and activation induced by silica: role of the Nrf2/Trx pathway

Alveolar macrophages are believed to induce oxidative stress via reactive oxygen species (ROS) when silica particles are inhaled. This process can contribute to the pathogenesis of silicosis, but the mechanism is unclear. A traditional Chinese herbal derivative, sodium tanshinone IIA sulfonate (STS)...

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Bibliographic Details
Published in:Toxicol Res (Camb)
Main Authors: Zhu, Zhonghui, Wang, Yan, Liang, Di, Yang, Gengxia, Chen, Li, Niu, Piye, Tian, Lin
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2015
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062030/
https://ncbi.nlm.nih.gov/pubmed/30090331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5tx00291e
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