Subcellular drug targeting illuminates local kinase action

Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases within intracellular compartments. We exploited the AKAP targeting concept to create g...

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Publicado en:eLife
Autores principales: Bucko, Paula J, Lombard, Chloe K, Rathbun, Lindsay, Garcia, Irvin, Bhat, Akansha, Wordeman, Linda, Smith, F Donelson, Maly, Dustin J, Hehnly, Heidi, Scott, John D
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930117/
https://ncbi.nlm.nih.gov/pubmed/31872801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52220
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