A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinases, Aurora A and Plk1, that i...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Hehnly, Heidi, Canton, David, Bucko, Paula, Langeberg, Lorene K, Ogier, Leah, Gelman, Irwin, Santana, L Fernando, Wordeman, Linda, Scott, John D
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2015
Sujets:
Biochemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612572/
https://ncbi.nlm.nih.gov/pubmed/26406118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09384
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