Multiple myeloma with 1q21 amplification is highly sensitive to MCL-1 targeting

Prosurvival BCL-2 family proteins are potent inhibitors of apoptosis and often overexpressed in lymphoid malignancies. In multiple myeloma (MM), MCL-1 expression contributes to survival of malignant plasma cells, and overexpression correlates with poor prognosis. In this study, we investigated wheth...

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Foilsithe in:Blood Adv
Main Authors: Slomp, Anne, Moesbergen, Laura M., Gong, Jia-nan, Cuenca, Marta, von dem Borne, Peter A., Sonneveld, Pieter, Huang, David C. S., Minnema, Monique C., Peperzak, Victor
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2019
Ábhair:
Lymphoid Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929383/
https://ncbi.nlm.nih.gov/pubmed/31856269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000702
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