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Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells

Multiple myeloma (MM), a treatable but incurable malignancy, is characterized by the growth of clonal plasma cells in protective niches in the bone marrow. MM cells depend on expression of BCL-2 family proteins, in particular MCL-1, for survival. The regulation of MCL-1 is complex and cell type-depe...

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Foilsithe in:Cell Death Dis
Main Authors: Slomp, Anne, Moesbergen, Laura M., Eldering, Eric, Kersten, Marie José, Minnema, Monique C., Peperzak, Victor
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930201/
https://ncbi.nlm.nih.gov/pubmed/33658484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03351-7
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