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Direct P70S6K1 inhibition to replace dexamethasone in synergistic combination with MCL-1 inhibition in multiple myeloma

Novel combination therapies have markedly improved the lifespan of patients with multiple myeloma (MM), but drug resistance and disease relapse remain major clinical problems. Dexamethasone and other glucocorticoids are a cornerstone of conventional and new combination therapies for MM, although the...

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Foilsithe in:Blood Adv
Main Authors: Spaan, Ingrid, Timmerman, Laura M., Kimman, Thomas, Slomp, Anne, Cuenca, Marta, van Nieuwenhuijzen, Niels, Moesbergen, Laura M., Minnema, Monique C., Raymakers, Reinier A., Peperzak, Victor
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270664/
https://ncbi.nlm.nih.gov/pubmed/34152396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003624
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