An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification

IL-6 signaling can be enhanced through transsignaling by the soluble IL-6 receptor (sIL-6r), allowing for the pleiotropic cytokine to affect cells it would not ordinarily have an effect on. Serum levels of sIL-6r can be used as an independent prognostic indicator and further stratify the GEP 70-gene...

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Detalhes bibliográficos
Main Authors: Stephens, Owen W., Zhang, Qing, Qu, Pingping, Zhou, Yiming, Chavan, Shweta, Tian, Erming, Williams, David R., Epstein, Joshua, Barlogie, Bart, Shaughnessy, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257015/
https://ncbi.nlm.nih.gov/pubmed/22072558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-367052
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