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The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors

Proteins that limit the activity of the tumour suppressor protein p53 are increasingly being targeted for inhibition in a variety of cancers. In addition to the development of small molecules, there has been interest in developing constrained (stapled) peptide inhibitors. A stapled peptide ALRN_6924...

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Foilsithe in:Int J Mol Sci
Main Authors: Kannan, Srinivasaraghavan, Partridge, Anthony W., Lane, David P., Verma, Chandra S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928821/
https://ncbi.nlm.nih.gov/pubmed/31795143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20235996
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