CGRP Signaling via CALCRL Increases Chemotherapy Resistance and Stem Cell Properties in Acute Myeloid Leukemia

The neuropeptide CGRP, acting through the G-protein coupled receptor CALCRL and its coreceptor RAMP1, plays a key role in migraines, which has led to the clinical development of several inhibitory compounds. Recently, high CALCRL expression has been shown to be associated with a poor prognosis in ac...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Gluexam, Tobias, Grandits, Alexander M., Schlerka, Angela, Nguyen, Chi Huu, Etzler, Julia, Finkes, Thomas, Fuchs, Michael, Scheid, Christoph, Heller, Gerwin, Hackl, Hubert, Harrer, Nathalie, Sill, Heinz, Koller, Elisabeth, Stoiber, Dagmar, Sommergruber, Wolfgang, Wieser, Rotraud
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928760/
https://ncbi.nlm.nih.gov/pubmed/31756985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20235826
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