CGRP Signaling via CALCRL Increases Chemotherapy Resistance and Stem Cell Properties in Acute Myeloid Leukemia

The neuropeptide CGRP, acting through the G-protein coupled receptor CALCRL and its coreceptor RAMP1, plays a key role in migraines, which has led to the clinical development of several inhibitory compounds. Recently, high CALCRL expression has been shown to be associated with a poor prognosis in ac...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Gluexam, Tobias, Grandits, Alexander M., Schlerka, Angela, Nguyen, Chi Huu, Etzler, Julia, Finkes, Thomas, Fuchs, Michael, Scheid, Christoph, Heller, Gerwin, Hackl, Hubert, Harrer, Nathalie, Sill, Heinz, Koller, Elisabeth, Stoiber, Dagmar, Sommergruber, Wolfgang, Wieser, Rotraud
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928760/
https://ncbi.nlm.nih.gov/pubmed/31756985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20235826
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