Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

CAG/CTG trinuncleotide repeats are fragile sequences that when expanded form DNA secondary structures and cause human disease. We evaluated CAG/CTG repeat stability and repair outcomes in histone H2 mutants in S. cerevisiae. Although the two copies of H2A are nearly identical in amino acid sequence,...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: House, Nealia CM, Polleys, Erica J, Quasem, Ishtiaque, De la Rosa Mejia, Marjorie, Joyce, Cailin E, Takacsi-Nagy, Oliver, Krebs, Jocelyn E, Fuchs, Stephen M, Freudenreich, Catherine H
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Assuntos:
Chromosomes and Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927750/
https://ncbi.nlm.nih.gov/pubmed/31804179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53362
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