The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies

Therapeutic mAbs are used to manage a wide range of cancers and autoimmune disorders. However, mAb-based treatments are not always successful, highlighting the need for a better understanding of the factors influencing mAb efficacy. Increased levels of oxidative stress associated with several diseas...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Gurjar, Shalom A., Wheeler, Jun X., Wadhwa, Meenu, Thorpe, Robin, Kimber, Ian, Derrick, Jeremy P., Dearman, Rebecca J., Metcalfe, Clive
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2019
Konular:
Immunology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926469/
https://ncbi.nlm.nih.gov/pubmed/31727737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010637
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