Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin

Thioredoxin 1 (TRX), an essential intracellular redox regulator, is also secreted by mammalian cells. Recently, we showed that TRX activates extracellular transglutaminase 2 via reduction of an allosteric disulfide bond. In an effort to identify other extracellular substrates of TRX, macrophages der...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Plugis, Nicholas M., Weng, Nielson, Zhao, Qinglan, Palanski, Brad A., Maecker, Holden T., Habtezion, Aida, Khosla, Chaitan
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126747/
https://ncbi.nlm.nih.gov/pubmed/30104382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805288115
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