Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain

The auxiliary β3-subunit is an important functional regulator of the cardiac sodium channel Nav1.5, and some β3 mutations predispose individuals to cardiac arrhythmias. The β3-subunit uses its transmembrane α-helix and extracellular domain to bind to Nav1.5. Here, we investigated the role of an unus...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Salvage, Samantha C., Zhu, Wandi, Habib, Zaki F., Hwang, Soyon S., Irons, Jennifer R., Huang, Christopher L. H., Silva, Jonathan R., Jackson, Antony P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926464/
https://ncbi.nlm.nih.gov/pubmed/31659116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010283
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