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How do DNA-bound proteins leave their binding sites? The role of facilitated dissociation

Dissociation of a protein from DNA is often assumed to be described by an off rate that is independent of other molecules in solution. Recent experiments and computational analyses have challenged this view by showing that unbinding rates (residence times) of DNA-bound proteins can depend on concent...

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Detalhes bibliográficos
Publicado no:Curr Opin Chem Biol
Main Authors: Erbaş, Aykut, Marko, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926143/
https://ncbi.nlm.nih.gov/pubmed/31586479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2019.08.007
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