Facilitated dissociation of transcription factors from single DNA binding sites

The binding of transcription factors (TFs) to DNA controls most aspects of cellular function, making the understanding of their binding kinetics imperative. The standard description of bimolecular interactions posits that TF off rates are independent of TF concentration in solution. However, recent...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Kamar, Ramsey I., Banigan, Edward J., Erbas, Aykut, Giuntoli, Rebecca D., Olvera de la Cruz, Monica, Johnson, Reid C., Marko, John F.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402408/
https://ncbi.nlm.nih.gov/pubmed/28364020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701884114
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