Facilitated dissociation of transcription factors from single DNA binding sites

The binding of transcription factors (TFs) to DNA controls most aspects of cellular function, making the understanding of their binding kinetics imperative. The standard description of bimolecular interactions posits that TF off rates are independent of TF concentration in solution. However, recent...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Kamar, Ramsey I., Banigan, Edward J., Erbas, Aykut, Giuntoli, Rebecca D., Olvera de la Cruz, Monica, Johnson, Reid C., Marko, John F.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402408/
https://ncbi.nlm.nih.gov/pubmed/28364020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701884114
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