Facilitated dissociation of transcription factors from single DNA binding sites

The binding of transcription factors (TFs) to DNA controls most aspects of cellular function, making the understanding of their binding kinetics imperative. The standard description of bimolecular interactions posits that TF off rates are independent of TF concentration in solution. However, recent...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kamar, Ramsey I., Banigan, Edward J., Erbas, Aykut, Giuntoli, Rebecca D., Olvera de la Cruz, Monica, Johnson, Reid C., Marko, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402408/
https://ncbi.nlm.nih.gov/pubmed/28364020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701884114
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