Facilitated dissociation of transcription factors from single DNA binding sites

The binding of transcription factors (TFs) to DNA controls most aspects of cellular function, making the understanding of their binding kinetics imperative. The standard description of bimolecular interactions posits that TF off rates are independent of TF concentration in solution. However, recent...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kamar, Ramsey I., Banigan, Edward J., Erbas, Aykut, Giuntoli, Rebecca D., Olvera de la Cruz, Monica, Johnson, Reid C., Marko, John F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402408/
https://ncbi.nlm.nih.gov/pubmed/28364020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701884114
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