β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward

Evidence shows that the neurotransmitter dopamine mediates the rewarding effects of nicotine and other drugs of abuse, while nondopaminergic neural substrates mediate the negative motivational effects. β2* nicotinic acetylcholine receptors (nAChR) are necessary and sufficient for the experience of b...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Grieder, Taryn E., Besson, Morgane, Maal-Bared, Geith, Pons, Stéphanie, Maskos, Uwe, van der Kooy, Derek
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925992/
https://ncbi.nlm.nih.gov/pubmed/31776253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908724116
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