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β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward
Evidence shows that the neurotransmitter dopamine mediates the rewarding effects of nicotine and other drugs of abuse, while nondopaminergic neural substrates mediate the negative motivational effects. β2* nicotinic acetylcholine receptors (nAChR) are necessary and sufficient for the experience of b...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6925992/ https://ncbi.nlm.nih.gov/pubmed/31776253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908724116 |
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