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Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF injection at dentate gyrus (DG) templates the formation of endogenous α-synuclein aggregates...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Elfarrash, Sara, Jensen, Nanna Møller, Ferreira, Nelson, Betzer, Cristine, Thevathasan, Jervis Vermal, Diekmann, Robin, Adel, Mohamed, Omar, Nisreen Mansour, Boraie, Mohamed Z., Gad, Sabry, Ries, Jonas, Kirik, Deniz, Nabavi, Sadegh, Jensen, Poul Henning
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924077/
https://ncbi.nlm.nih.gov/pubmed/31856920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0865-5
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