Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF injection at dentate gyrus (DG) templates the formation of endogenous α-synuclein aggregates...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Elfarrash, Sara, Jensen, Nanna Møller, Ferreira, Nelson, Betzer, Cristine, Thevathasan, Jervis Vermal, Diekmann, Robin, Adel, Mohamed, Omar, Nisreen Mansour, Boraie, Mohamed Z., Gad, Sabry, Ries, Jonas, Kirik, Deniz, Nabavi, Sadegh, Jensen, Poul Henning
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924077/
https://ncbi.nlm.nih.gov/pubmed/31856920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0865-5
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