Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF injection at dentate gyrus (DG) templates the formation of endogenous α-synuclein aggregates...

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Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: Elfarrash, Sara, Jensen, Nanna Møller, Ferreira, Nelson, Betzer, Cristine, Thevathasan, Jervis Vermal, Diekmann, Robin, Adel, Mohamed, Omar, Nisreen Mansour, Boraie, Mohamed Z., Gad, Sabry, Ries, Jonas, Kirik, Deniz, Nabavi, Sadegh, Jensen, Poul Henning
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Methodology Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924077/
https://ncbi.nlm.nih.gov/pubmed/31856920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0865-5
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