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Fully moderated t-statistic in linear modeling of mixed effects for differential expression analysis

BACKGROUND: Gene expression profiling experiments with few replicates lead to great variability in the estimates of gene variances. Toward this end, several moderated t-test methods have been developed to reduce this variability and to increase power for testing differential expression. Most of thes...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Yu, Lianbo, Zhang, Jianying, Brock, Guy, Fernandez, Soledad
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923909/
https://ncbi.nlm.nih.gov/pubmed/31861977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-3248-9
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