Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling

BACKGROUND: The mechanistic (or mammalian) target of rapamycin (mTOR), a Ser/Thr kinase, associates with different subunits forming two functionally distinct complexes, mTORC1 and mTORC2, regulating a diverse set of cellular functions in response to growth factors, cellular energy levels, and nutrie...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Lone, Mehraj-U-Din, Miyan, Javed, Asif, Mohammad, Malik, Showkat A., Dubey, Parul, Singh, Varsha, Singh, Kavita, Mitra, Kalyan, Pandey, Deepali, Haq, Wahajul, Amita, Himanshi, Singh, Prince Kumar, Kiess, Wieland, Kaessner, Franziska, Garten, Antje, Bhadauria, Smrati
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921532/
https://ncbi.nlm.nih.gov/pubmed/31856761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6422-6
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