Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock — rationale and design of a multicenter randomized controlled superiority trial

BACKGROUND: Antibiotic exposure is often inadequate in critically ill patients with severe sepsis or septic shock and this is associated with worse outcomes. Despite markedly altered and rapidly changing pharmacokinetics in these patients, guidelines and clinicians continue to rely on standard dosin...

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Detalles Bibliográficos
Publicado en:Trials
Autores principales: Roggeveen, Luca F., Fleuren, Lucas M., Guo, Tingjie, Thoral, Patrick, de Grooth, Harm Jan, Swart, Eleonora L., Klausch, Thomas L. T., van der Voort, Peter H. J., Girbes, Armand R. J., Bosman, Rob J., Elbers, Paul W. G.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Study Protocol
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921499/
https://ncbi.nlm.nih.gov/pubmed/31852491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-019-3911-5
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