Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock — rationale and design of a multicenter randomized controlled superiority trial

BACKGROUND: Antibiotic exposure is often inadequate in critically ill patients with severe sepsis or septic shock and this is associated with worse outcomes. Despite markedly altered and rapidly changing pharmacokinetics in these patients, guidelines and clinicians continue to rely on standard dosin...

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Vydáno v:Trials
Hlavní autoři: Roggeveen, Luca F., Fleuren, Lucas M., Guo, Tingjie, Thoral, Patrick, de Grooth, Harm Jan, Swart, Eleonora L., Klausch, Thomas L. T., van der Voort, Peter H. J., Girbes, Armand R. J., Bosman, Rob J., Elbers, Paul W. G.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Study Protocol
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921499/
https://ncbi.nlm.nih.gov/pubmed/31852491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-019-3911-5
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