Age-associated sperm DNA methylation patterns do not directly persist trans-generationally

BACKGROUND: The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly understood. The well-defined impact of aging on sperm DNA methylation represents an e...

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Detalles Bibliográficos
Publicado en:Epigenetics Chromatin
Main Authors: Jenkins, Timothy G., James, Emma R., Aston, Kenneth I., Salas-Huetos, Albert, Pastuszak, Alexander W., Smith, Ken R., Hanson, Heidi A., Hotaling, James M., Carrell, Douglas T.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921445/
https://ncbi.nlm.nih.gov/pubmed/31856899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0323-4
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