Age-associated sperm DNA methylation patterns do not directly persist trans-generationally

BACKGROUND: The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly understood. The well-defined impact of aging on sperm DNA methylation represents an e...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Jenkins, Timothy G., James, Emma R., Aston, Kenneth I., Salas-Huetos, Albert, Pastuszak, Alexander W., Smith, Ken R., Hanson, Heidi A., Hotaling, James M., Carrell, Douglas T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921445/
https://ncbi.nlm.nih.gov/pubmed/31856899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0323-4
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