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Computational approaches for effective CRISPR guide RNA design and evaluation
The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/ CRISPR-associated (Cas) system has emerged as the main technology for gene editing. Successful editing by CRISPR requires an appropriate Cas protein and guide RNA. However, low cleavage efficiency and off-target effects hamper th...
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| Publicado no: | Comput Struct Biotechnol J |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Research Network of Computational and Structural Biotechnology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6921152/ https://ncbi.nlm.nih.gov/pubmed/31890142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2019.11.006 |
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