DeepCRISPR: optimized CRISPR guide RNA design by deep learning

A major challenge for effective application of CRISPR systems is to accurately predict the single guide RNA (sgRNA) on-target knockout efficacy and off-target profile, which would facilitate the optimized design of sgRNAs with high sensitivity and specificity. Here we present DeepCRISPR, a comprehen...

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Vydáno v:Genome Biol
Hlavní autoři: Chuai, Guohui, Ma, Hanhui, Yan, Jifang, Chen, Ming, Hong, Nanfang, Xue, Dongyu, Zhou, Chi, Zhu, Chenyu, Chen, Ke, Duan, Bin, Gu, Feng, Qu, Sheng, Huang, Deshuang, Wei, Jia, Liu, Qi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020378/
https://ncbi.nlm.nih.gov/pubmed/29945655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1459-4
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