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Development and Evaluation of Physiologically Based Pharmacokinetic Drug–Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations

The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug–disease models by allowing incorporation of relevant pathophysiological changes. The aim of the present work was to explore and identify the differences in rifampicin pharmacokinetics (PK) after the...

詳細記述

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書誌詳細
出版年:Pharmaceutics
主要な著者: Rasool, Muhammad F., Khalid, Sundus, Majeed, Abdul, Saeed, Hamid, Imran, Imran, Mohany, Mohamed, Al-Rejaie, Salim S., Alqahtani, Faleh
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921057/
https://ncbi.nlm.nih.gov/pubmed/31694244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11110578
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