Development and Evaluation of Physiologically Based Pharmacokinetic Drug–Disease Models for Predicting Rifampicin Exposure in Tuberculosis and Cirrhosis Populations

The physiologically based pharmacokinetic (PBPK) approach facilitates the construction of novel drug–disease models by allowing incorporation of relevant pathophysiological changes. The aim of the present work was to explore and identify the differences in rifampicin pharmacokinetics (PK) after the...

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Veröffentlicht in:Pharmaceutics
Hauptverfasser: Rasool, Muhammad F., Khalid, Sundus, Majeed, Abdul, Saeed, Hamid, Imran, Imran, Mohany, Mohamed, Al-Rejaie, Salim S., Alqahtani, Faleh
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921057/
https://ncbi.nlm.nih.gov/pubmed/31694244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11110578
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