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The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance

The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs) itself contributes to the drug resistance in...

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Detaylı Bibliyografya
Yayımlandı:Biomolecules
Asıl Yazarlar: Ruzickova, Eliska, Skoupa, Nikola, Dolezel, Petr, Smith, Dennis A., Mlejnek, Petr
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921012/
https://ncbi.nlm.nih.gov/pubmed/31683643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9110675
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