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The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance

The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs) itself contributes to the drug resistance in...

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Pubblicato in:Biomolecules
Autori principali: Ruzickova, Eliska, Skoupa, Nikola, Dolezel, Petr, Smith, Dennis A., Mlejnek, Petr
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921012/
https://ncbi.nlm.nih.gov/pubmed/31683643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9110675
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