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Lysosomal Fusion: An Efficient Mechanism Increasing Their Sequestration Capacity for Weak Base Drugs without Apparent Lysosomal Biogenesis

Lysosomal sequestration of anticancer therapeutics lowers their cytotoxic potential, reduces drug availability at target sites, and contributes to cancer resistance. Only recently has it been shown that lysosomal sequestration of weak base drugs induces lysosomal biogenesis mediated by activation of...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Skoupa, Nikola, Dolezel, Petr, Mlejnek, Petr
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022710/
https://ncbi.nlm.nih.gov/pubmed/31947839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10010077
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