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The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance

The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs) itself contributes to the drug resistance in...

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Bibliografiska uppgifter
I publikationen:Biomolecules
Huvudupphovsmän: Ruzickova, Eliska, Skoupa, Nikola, Dolezel, Petr, Smith, Dennis A., Mlejnek, Petr
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921012/
https://ncbi.nlm.nih.gov/pubmed/31683643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9110675
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