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Two Successive Inversional Vβ rearrangements on a Single Tcrb Allele Can Contribute to the TCRβ Repertoire
Mammalian TCRβ loci contain 30 Vβ gene segments upstream and in the same transcriptional orientation as two DJCβ clusters, and a downstream Vβ (TRBV31) in the opposite orientation. The textbook view is upstream Vβs rearrange only by deletion, and TRBV31 rearranges only by inversion, to create VβDJCβ...
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| Udgivet i: | J Immunol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6920540/ https://ncbi.nlm.nih.gov/pubmed/31740488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901105 |
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